Khizr Khan was not only the founder of the Saiyyid Dynasty but also its ablest ruler. Khizr Khan did not rule as a sovereign ruler but professed to rule as the deputy of Timur's son and successor. He assumed the title of Shah and got the Khutba read in his name.
In 1412 he conquered Gujarat, Gwalior and Jaunpur. In 1416 he defeated Bayana and in 1421 he attacked Mewat. Due to the illness he died in the year 1421. He was succeeded by his son Mubarak Shah in 1421 who ruled till 1434. He was succeeded by his son Muhammad Shah in 1434 who ruled till 1445 AD. He remained in his capital sunk in indolence and pleasure. He was succeeded by his son Alauddin Alam Shah 1445-51. He was the weakest ruler of the Saiyyid Dynasty. He was deposed by Bahlol Lodhi, the powerful governor of Lahore and Sirhind who founded the Lodhi dynasty.